biggest killers case study

Tackling the world’s biggest killers: The PILL, IMPACT, Kanyini GAP, UMPIRE & TRIUMPH studies and the SPACE Collaboration

Twenty years of ground-breaking research from The George Institute has proven the effectiveness of combining multiple medications into one pill to prevent heart attacks and strokes – the world’s leading causes of premature death. By simplifying treatment regimens and making recommended medications more affordable for people at highest risk of cardiovascular disease, our researchers have challenged conventional thinking about how cardiovascular risk factors should be treated, with the potential to save millions of lives if implemented globally.

 

 

 

better treatments

Transforming treatments, saving lives: The SAFE, SAFE-TBI, CHEST & PLUS studies

Our research has saved many thousands of lives and hundreds of millions of dollars by changing the way the medical world views one of the most common intensive care treatments. Our studies have influenced intensive care treatment guidelines worldwide, prevented harmful yet common treatment choices, and demonstrated that cheaper treatments can be safer than more expensive ones. By tackling what was previously considered ‘impossible’ in intensive care research, our researchers initiated a culture of critical thinking in one of the most challenging and expensive areas of healthcare.

 

 

Coronavirus Preparedeness

Frontline health workers in COVID-19 prevention and control: rapid evidence synthesis

COVID-19 is a respiratory illness caused by a newly discovered coronavirus was first reported in Wuhan, China in December 2019. Subsequently it has spread to 187 countries and territories with more than 294,110 cases and 12,944 deaths globally.

Countries across the world are introducing measures to prevent its spread, increasing capacity for quarantine and building capacity of hospitals (particularly intensive care units) to manage positive cases. With efforts to prevent community transmission of COVID-19 being a top priority, ensuring preparedness of frontline health workers (FLHWs) is essential.

The Government of India is embarking on a mammoth task to prevent COVID-19 spread among communities. The Rapid Evidence Synthesis team received a request to support the planning and development of resources for ensuring preparedness of FLHWs for COVID-19 . The rapid evidence synthesis was conducted in a period of three days.

The findings highlight what we can learn from recent pandemics such that we are prepared for potential scenarios and challenges due to COVID-19. Key issues which decision-makers need to consider, based on available evidence are:

  1. FLHWs will be at an increased risk of COVID-19, even in the course of their normal activities. It is essential to provide personal protective equipment (gloves, surgical masks, hand sanitisers; N95 masks if involved in contact tracing) in adequate quantity. This should be accompanied by training on proper usage in the early phase itself.
  2. Disruption in supply-chain, logistics and supportive supervision might be expected and this would impact routine service delivery. Advice should be given on which activities are to continue and which might be postponed. Guidelines and protocols for conducting additional activities and training is required.
  3. Engaging FLHWs who continue to perform routine service delivery in additional contact identification and listing, is not without its risk including that of transmission of COVID-19. A role focussed on creating awareness and support for prevention and countering social stigma is recommended for FLHWs.
  4. FLHWs might experience stigmatisation, isolation and been socially ostracised. Providing psychosocial support, non-performance-based incentives, additional transport allowance, child-care support should be planned. Awards and recognition are required for motivation.
  5. Social distancing related measures might not be appropriate in many contexts like urban slums, large/joint families, those living in small houses and the homeless.

The rapid evidence synthesis goes beyond research evidence and integrates multiple types and levels of evidence from across the world. The inventories provided serve as a ready resource guide for any country considering the use of FLHWs to control COVID-19.

The full rapid evidence synthesis and supporting appendices are available below

Download full report (PDF 319 KB)

This report is a part of the Ensuring Health Systems Capacity for COVID-19 and Beyond: Evidence Series”.
The series aims to provide high quality and contextualised evidence from systematic reviews or rapid evidence synthesis to work on the opportunity the COVID-19 scenario offers i.e., to build a strong, resilient and equitable health system in India and other low and middle income countries.

External Resources

Community health workers for pandemic response: a rapid evidence synthesis - an article published in BMJ Global Health

New WHO Collaborating Centre

New WHO Collaborating Centre will target injury and trauma

In November 2018, The George Institute was designated a WHO Collaborating Centre for Injury Prevention and Trauma Care, enabling us to develop and implement effective strategies for prevention, as well as deliver affordable and accessible care globally.

The George Institute has been working successfully with WHO for many years on a range of injury and trauma projects, including the synthesis of evidence, developing good practice guides, organising and hosting regional injury meetings and workshops, collaborating on falls, burns, drowning, and road safety projects, to supervising and mentoring injury researchers around the world.

More information here.

Low Cost

SMARThealth technology platform proves effective in managing cardiovascular risk

SMARThealth is a mobile device-based clinical decision support system developed by The George Institute for Global Health that allows community health workers to assess cardiovascular (CVD) risk using basic equipment and refer those at high risk to nurses or physicians for further consultation.

CVD is estimated to be the cause of one third of all deaths in Indonesia in 2016, but current data suggests that less than one third of those with moderate to high risk of CVD receive any preventive care.

A recent study involving rural villagers in Malang, Indonesia, who were identified as being at high risk of cardiovascular disease, was set up to evaluate how effective SMARThealth could be when used within a complex local health system.

SMARThealth resulted in a significant increase in the use of optimal combinations of preventive medications (a blood pressure lowering drug together with a statin and aspirin in those with previous CVD) among highrisk people. In particular, SMARThealth resulted in large increases in the use of blood pressure lowering drugs in the intervention villages compared to the control villages reductions in blood pressure. Following the success of this study, the Malang district government is now aiming to scale-up SMARThealth to around 400 villages over the next three years.

A consortium of researchers including the George Institute for Global Health, the University of Brawijaya and the University of Manchester have been funded by the Australian National Health and Medical Research Council to provide technical assistance for, and to evaluate, this scale-up.

The Malang study was funded by Give2Asia on the recommendation of The Pfizer Foundation and NHMRC program grant APP1052555. The Pfizer Foundation is a charitable organisation established by Pfizer Inc. It is a separate legal entity from Pfizer Inc. with distinct legal restrictions.

Read more about this research here.

More about SMARThealth impact here.

Low cost mobile technology shifts the dial on cardiovascular risk in rural Indonesia

Media release

SYDNEY, AUG 29. An Australian-developed mobile app supported system that helps health systems identify and better manage people at high risk of cardiovascular disease has been shown to improve the use of appropriate medications and lower blood pressure in rural Indonesian communities.

News and events

Media contacts

United Kingdom

Anastasia Alden
Communications Manager, UK

aalden@georgeinstitute.org
+44 7918 553680

United Kingdom

Alex Bentley
Communications Consultant. UK

abentley@georgeinstitute.org.uk
+44 7472 750054