George Health Enterprises
George Health Enterprises (GHE) is our commercial arm and a healthcare company with a unique vision - an innovative business with global impact that develops effective, affordable treatments and technologies that better treat and manage serious, chronic medical conditions. We work in established countries such as Australia, Europe, and the US and emerging markets such as India and China, focused solely on the most common chronic conditions.
Chronic diseases are the leading causes of death globally. The world is facing a pandemic of chronic diseases such as heart and respiratory diseases, stroke, and cancer. Around 40 million people die from these causes each year, many under 70 years. The human and ﬁnancial costs are enormous – the four leading chronic diseases were estimated to have cost more than $6 trillion globally in 2010. This burden is projected to rise, and the costs to increase to $30 trillion over the next 20 years.
There is increasing demand for new treatments and ways to manage chronic disease, driven by a growing ageing population and lack of access to appropriate medical treatments and services globally. To meet this need, GHE has three established businesses that are poised for signiﬁcant growth, and integrated in a way that enables innovative health products and services to be taken all the way from concept to market, in a relatively short time frame. This capability is usually only available within big pharma or medical technology companies.
GHE has exclusive commercial rights to all intellectual property of The George, as well as exclusive access to expertise and support from the Institute. The Institute’s focus on late stage clinical research for chronic disease means that medicines and technologies are proven before GHE commercialises, resulting in a much higher probability of success rate than is usual in the industry.
An experienced management team leads GHE with a long industry track record in drug development and commercialisation, biotechnology, healthcare delivery and venture capital investment in established and emerging markets. Coupled with the global scientific leadership of The George, our business has potential for real social and economic impact.
“We are a unique business – with a vision to provide affordable, sustainable solutions that help populations have equal access to healthcare irrespective of their location or economic situation. This is not only socially responsible, it is the foundation of a robust business opportunity.” Staph Leavenworth-Bakali, President and CEO, George Health Enterprises
George Health Enterprises consists of three divisions:
- George Clinical
- George Medicines
- George Health Technologies
George Medicines is focused on developing novel, high-quality drug treatments that are affordable, safe and effective. The need for new medicines is vital as over 50% of people worldwide are not receiving adequate care for chronic disease because they cannot afford or access them.
There are around 2 billion people globally with one or more cardiometabolic diseases. Hypertension is the most common, followed by diabetes. Another half billion have established coronary, cerebrovascular, renovascular or peripheral vascular disease. Three quarters of these patients live in emerging markets in East and South Asia, Central Asia (including Russia), South America, South Africa and the Middle East.
By the end of the decade, global sales for all cardiometabolic drugs will exceed $200 billion. Over the same period, the global market for antihypertensive drugs alone will exceed $40 billion annually, while the market for diabetes drugs will surpass this, reaching more than $70 billion annually.
George Medicines is developing a series of affordable high-quality novel drug formulations proven by research at The George. Using the infrastructure of George Clinical and the scientiﬁc expertise of the Institute, George Medicines can move quickly into late-stage drug development (rather than early high-risk stages of drug discovery and development). Our ﬁrst product is a combination medication, for patients with a history of coronary, cerebrovascular, or peripheral vascular diseases. A multi-million investment in the development of this product was secured in Australia from our partner, the global health insurer, BUPA, under the name SmartGenRx. The product is expected to be launched in 2019. George Medicines has a pipeline of several other products, some of which have patents pending.
George Health Technologies
George Health Technologies is developing a Digital Clinical Intelligence (DCI) system that has been proven to improve the treatment of patients at high risk of cardiovascular disease in Australia and in emerging market settings.
Many patients have co-existing chronic diseases and find it hard to adhere to their treatment long-term, particularly with multiple drugs. In resource-poor settings, these problems are compounded by limited access to physicians, limited skills of other healthcare providers, limited drug options and the added complexity of having infectious diseases such as tuberculosis and HIV/AIDS.
DCI is a disease management system developed by physicians and researchers at The George. This innovative digital health solution generates real-time, state-of-the-art personalised treatment plans for cardiovascular disease; and generates and monitors personalised care plans based on approved clinical guidelines and the best available scientiﬁc evidence.
We are also looking at opportunities to expand DCI to manage other common chronic conditions such as respiratory disease and depression. Currently we are evaluating potential partnerships in Australia, China, India and the Middle East. Interest has also been expressed in using an extended version of the system to manage patients with HIV who suffer accelerated cardiometabolic complications, due in part to side effects of antiretroviral therapy.