TY - JOUR AU - Group GEM AU - Dwyer T AU - Venn Alison AU - Thomas Nancy AU - Kanetsky Peter AU - Armstrong Bruce AU - Cust Anne AU - Anton-Culver Hoda AU - Gruber Stephen AU - Luo Li AU - Orlow Irene AU - Gallagher Richard AU - Zanetti Roberto AU - Rosso Stefano AU - Sacchetto Lidia AU - Begg Colin AU - Berwick Marianne AU - Shi Yang AU - Corrales-Guerrero Sergio AU - Marrett Loraine AU - Busam Klaus AB -

Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.

BT - Pigment Cell Melanoma Res C1 - https://www.ncbi.nlm.nih.gov/pubmed/28990310?dopt=Abstract DO - 10.1111/pcmr.12653 IS - 2 J2 - Pigment Cell Melanoma Res LA - eng N2 -

Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.

PY - 2018 SP - 287 EP - 296 T2 - Pigment Cell Melanoma Res TI - The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival. VL - 31 SN - 1755-148X ER -