01992nas a2200361   4500000000100000008004100001100001400042700001200056700001600068700001700084700001900101700002000120700001400140700002200154700001900176700001100195700001600206700002200222700002000244700001800264700002000282700001500302700002100317700001300338700002900351700002000380700001600400245013300416300001200549490000700561520104800568022001401616       2018                            d1 aGroup GEM1 aDwyer T1 aVenn Alison1 aThomas Nancy1 aKanetsky Peter1 aArmstrong Bruce1 aCust Anne1 aAnton-Culver Hoda1 aGruber Stephen1 aLuo Li1 aOrlow Irene1 aGallagher Richard1 aZanetti Roberto1 aRosso Stefano1 aSacchetto Lidia1 aBegg Colin1 aBerwick Marianne1 aShi Yang1 aCorrales-Guerrero Sergio1 aMarrett Loraine1 aBusam Klaus00aThe interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival.  a287-2960 v313 a<p>Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.</p>  a1755-148X