The George Institute started its work in the United Kingdom by establishing an office in London in 2004 to house a research group analysing investment trends in the development of new treatments for neglected diseases. In 2008, the group received a major award from the Bill & Melinda Gates Foundation.
In 2010 The George Centre for Healthcare Innovation was established in partnership with the University of Oxford, with generous support from the Oxford Martin School founded by Dr James Martin. In 2013 the centre changed its name to The George Institute for Global Health, UK. The same year, the Institute organised the "Big Change: Sustainable Healthcare for the 21st Century" conference, a multi-disciplinary event focused on strategies to accelerate affordable, innovative healthcare solutions in resource-poor settings. The Institute also played the lead role in setting up the Oxford-India Health Research Network, which is a multi-disciplinary, voluntary and informal network of health-related and India-focussed researchers and students at the University.
In November 2015, the Institute moved to the Nuffield Department of Obstetrics and Gynaecology, within the Medical Sciences Division, creating new opportunities to work together towards improving the health of women and babies around the world, and contributing to the Institute's mission globally to increase access to quality health care for millions of people worldwide - with a particular focus on vulnerable populations in resource-poor settings.